I have just done this, no problem. As others have said tie the brake caliper out of the way. It's quite heavy but not impossibly so. The half shaft comes out with it but it's quite easy to get back.
I have read that you can install a new seal without removing the hub by cutting the new seal and installing it under the seal cover with the cut at the top. In fact this is what I found when I replaced mine, which is probably why I needed to replace it....